This report describes the potential of using hydrogen in industrial processes for the decarbonization of industry through the gradual replacement of fossil fuels. Operational and economic data from case studies and pilot plants have been acquired to objectively evaluate the technical and economic cost-effectiveness of using hydrogen and to identify adaptable industrial technologies. Critical aspects, such as technological and economic obstacles, have been analyzed. The impact of hydrogen use on industrial processes has been assessed to identify critical conditions that could limit the application of currently available technologies. Currently, there are very few new hydrogen applications outside the chemical and petrochemical sectors. In particular, for a highly energy-intensive sector like steelmaking, hydrogen can currently replace fossil fuels through a technology already in use, which involves the direct reduction of iron ore, leading to significant environmental benefits. Several initiatives have been identified for this sector, even at a high level of technological maturity. The necessary actions for partial and full hydrogen use are discussed, along with elements for a possible roadmap, including estimated timelines, and potential new production scenarios, all supported by a technical-economic analysis. It has been estimated that by 2050, the steel industry will have technological solutions available for full or significant decarbonization. In other industrial sectors, such as those considered in this study (cement, non-ferrous metals, glass, plastics), hydrogen adoption is still in a somewhat conceptual stage, with few real examples and poorly defined guidelines. However, it has emerged that partial decarbonization is technologically feasible through hydrogen blending in the natural gas network for heat production, up to a maximum of 50%, provided there are appropriate adjustments and minor modifications to burners.